Ismael G. M.
- Country
- Spain
- Department
- Allergology
Research Overview
- Long-term safety and efficacy of subcutaneous lunsekimig in adults with asthma: An open-label extension study
- Efficacy and safety of grass and olive pollen extract combination therapy versus placebo in patients with allergic rhinoconjunctivitis and asthma
- Efficacy and Safety of Depigmented Polymerized Grass Pollen Extracts in Patients with Allergic Rhinoconjunctivitis and Controlled Asthma: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 209 of 491 partner sites.
Specializations
Allergic and Respiratory Disorders
The investigator concentrates on diseases driven by IgE‑mediated mechanisms and airway hyper‑responsiveness.
- Allergic rhinoconjunctivitis with or without asthma
- Moderate to severe asthma uncontrolled by high‑dose inhaled corticosteroids
- Chronic rhinosinusitis with nasal polyposis
Research aims to define biologic targets that can modify disease course and reduce exacerbations.
Hematologic Malignancies
Focused on clonal proliferations of blood and marrow cells, particularly those with adverse cytogenetics.
- Acute myeloid leukemia with high‑risk molecular profiles
- Myelodysplastic syndromes progressing to AML
- Chronic lymphocytic leukemia and related B‑cell neoplasms
- Multiple myeloma in relapsed or refractory settings
Efforts include integrating targeted agents and immune‑based strategies to improve survival.
Solid Tumor Oncology
Broad engagement with advanced malignancies across organ systems, emphasizing molecularly defined subsets.
- Non‑small cell lung cancer with EGFR, ALK or KRAS alterations
- Breast cancer—including HER2‑positive, triple‑negative and HR+/HER2‑negative subtypes
- Colorectal carcinoma with microsatellite instability or BRAF mutations
- Gastro‑esophageal adenocarcinoma and gastric cancer
- Urothelial carcinoma of bladder and upper tract
The program prioritizes biomarker‑driven therapies and combination regimens.
Autoimmune and Inflammatory Diseases
Investigations target systemic immune dysregulation affecting skin, joints and organs.
- Systemic lupus erythematosus with cutaneous involvement
- Psoriatic arthritis and moderate to severe plaque psoriasis
- Dermatomyositis and polymyositis
- Inflammatory bowel disease (Crohn’s disease and ulcerative colitis)
Therapeutic goals include achieving durable remission while minimizing systemic toxicity.
Cardiovascular and Metabolic Conditions
Research addresses high‑risk atherosclerotic disease and metabolic disturbances linked to obesity.
- Atherosclerotic cardiovascular disease prevention in high‑risk patients
- Heart failure with preserved ejection fraction (HFpEF) associated with obesity
- Severe hypertriglyceridemia resistant to conventional therapy
- Hypertension uncontrolled despite multi‑drug regimens
Efforts focus on novel pharmacologic agents and lifestyle integration to reduce cardiovascular events.
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