UZ Leuven

Address
Herestraat 49

Sponsor Overview

assignment
81
sponsored trials
science
114
molecules
location_city
151
research centres
public
8
countries
person_search
317
investigators

Specializations

Gastroenterology and Inflammatory Bowel Disease

Research activity includes Crohn’s disease, acute severe ulcerative colitis, pouchitis, short bowel syndrome, irritable bowel syndrome, functional dyspepsia, gastro-oesophageal reflux disease, and opioid-induced constipation.

  • Inflammatory bowel disease surgery and recurrence
  • Intestinal motility and upper gastrointestinal symptoms
  • Supportive care in gastrointestinal disorders

Additional work spans infliximab treatment strategies, proton pump inhibitor deprescribing, and symptom-focused care in chronic digestive disease.

Oncology and Hematologic Malignancy

The oncology portfolio covers gastro-esophageal adenocarcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, rectal cancer, breast cancer, prostate cancer, ovarian cancer, and malignant melanoma.

  • Targeted treatment in receptor-defined cancers
  • Metastasis-directed approaches in advanced solid tumors
  • Perioperative and neoadjuvant cancer care

Studies also address febrile neutropenia, tumor imaging with PET/CT, and treatment selection in clinically challenging oncologic settings.

Neurology, Neurodegeneration, and Developmental Disorders

Clinical research includes Alzheimer disease, frontotemporal dementia, Lewy body disease, Parkinson’s disease, multiple system atrophy, amyotrophic lateral sclerosis, spinal muscular atrophy, autism spectrum disorder, cerebral palsy, traumatic brain injury, and drug-resistant epilepsy.

  • Neurodegenerative disease characterization
  • Motor and cognitive outcome assessment
  • Pediatric neurodevelopmental care

Imaging and biomarker work extends to tau pathology, carotid atherosclerosis, and functional brain circuit studies.

Rheumatology, Dermatology, and Immune-Mediated Disease

Studies focus on rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, giant cell arteritis, IgG4-related disease, hidradenitis suppurativa, chronic rhinosinusitis with nasal polyps, and nonsteroidal anti-inflammatory drug-exacerbated respiratory disease.

  • Biologic and targeted immune therapy
  • Vasculitis and inflammatory airway disease
  • Inflammatory skin and joint disorders

Research also addresses dupilumab, rituximab, tofacitinib, and anti-TNF strategies in immune-mediated conditions.

Perioperative Care, Critical Care, and Clinical Pharmacology

Trials span infective endocarditis, severe community-acquired pneumonia, prosthetic joint infections, fracture-related infections, cardiac surgery, obstetric and fetal surgery, and intensive care management in critically ill patients.

  • Antimicrobial treatment optimization
  • Perioperative analgesia and anesthesia
  • Drug exposure and pharmacokinetics in complex care

Additional interests include ceftazidime-avibactam, clindamycin, apixaban, ketamine, oxytocin, and naloxegol.

Sponsored Trials

Trial Name Country Status
A multicenter uncontrolled, open label, prospective non-comparative single arm phase II study with bicalutamide (an antiandrogen) in combination with abemaciclib (an oral CDK 4/6 inhibitor) in 4 cohorts of locoregionally advanced inoperable or metastatic AR positive triple-negative breast cancer (AR+ TNBC).Belgium BelgiumRecruiting
A Randomized, Double-Blind, Placebo-Controlled Crossover Study of Clebopride Hydrogen Maleate in Patients with Rumination SyndromeBelgium BelgiumNot Recruiting
Bisoprolol Effects on Quality of Life and Cardiac Rehabilitation Outcomes in Post-Myocardial Infarction Patients with Preserved Ejection FractionBelgium BelgiumRecruiting
Comparative Diagnostic Efficacy of [18F]AlF-FAPI-74 Versus [18F]FDG PET/CT in Fever of Unknown Origin, IgG4-Related Disease, and Axial SpondyloarthritisBelgium BelgiumRecruiting
Comparative Evaluation of Cardiac [18F]-MFBG PET and [123I]-MIBG SPECT in Differentiating Parkinson's Disease, Multiple System Atrophy, Dementia with Lewy Bodies, and Alzheimer's DiseaseBelgium BelgiumRecruiting
Comparative Study of Preservative-Free vs. Preserved Dexamethasone and Diclofenac Eye Drops Post-Cataract SurgeryBelgium BelgiumNot Recruiting
Congenital CMV treated with valaciclovir during pregnancy: a prospective cohort studyBelgium BelgiumFrance FranceNot Recruiting
Determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients: impact of on-demand use, adjustment of therapy or discontinuation.Belgium BelgiumFrance FranceNot Recruiting
Diagnostic Accuracy of [18F]AlF‑FAPI‑74 PET/CT for Detecting Deep Infiltrating and Superficial Peritoneal Endometriosis in Suspected PatientsBelgium BelgiumRecruiting
Diagnostic Accuracy of [18F]AlF‑FAPI‑74 PET/CT vs Power Doppler Ultrasound for Early Psoriatic Arthritis in Psoriasis with ArthralgiaBelgium BelgiumNot Yet Recruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
8
Exclusive Molecules
out of 114 total (7% not shared with other sponsors)

This sponsor works with 114 molecules, of which 8 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
21%
Return partnership rate
32 of 151 sites collaborated multiple times

This sponsor has worked with 151 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Digestive System Diseases14 trials
    284 other sponsors
  • 2.
    Neoplasms11 trials
    875 other sponsors
  • 3.
    Musculoskeletal Diseases7 trials
    246 other sponsors
  • 4.
    Bacterial Infections and Mycoses6 trials
    188 other sponsors
  • 5.
    Cardiovascular Diseases6 trials
    372 other sponsors
  • 6.
    Nervous System Diseases6 trials
    459 other sponsors
  • 7.
    Immune System Diseases5 trials
    339 other sponsors
  • 8.
    Nutritional and Metabolic Diseases5 trials
    224 other sponsors
  • 9.
    Physiological processes5 trials
    28 other sponsors
  • 10.
    Psychological Phenomena5 trials
    20 other sponsors
  • 11.
    Anesthesia and Analgesia4 trials
    101 other sponsors
  • 12.
    Behavior and Behavior Mechanisms4 trials
    41 other sponsors
  • 13.
    Therapeutics4 trials
    90 other sponsors
  • 14.
    Diagnosis3 trials
    89 other sponsors
  • 15.
    Female Urogenital Diseases and Pregnancy Complications3 trials
    148 other sponsors
  • 16.
    Investigative Techniques3 trials
    37 other sponsors
  • 17.
    Behavioral Disciplines and Activities2 trials
    21 other sponsors
  • 18.
    Digestive System and Oral Physiological Phenomena2 trials
    16 other sponsors
  • 19.
    Male Urogenital Diseases2 trials
    125 other sponsors
  • 20.
    Mental Disorders2 trials
    154 other sponsors
  • 21.
    Otorhinolaryngologic Diseases2 trials
    52 other sponsors
  • 22.
    Skin and Connective Tissue Diseases2 trials
    257 other sponsors
  • 23.
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities1 trial
    168 other sponsors
  • 24.
    Equipment and Supplies1 trial
    2 other sponsors
  • 25.
    Eye Diseases1 trial
    144 other sponsors
  • 26.
    Immune system processes1 trial
    69 other sponsors
  • 27.
    Microbiological Phenomena1 trial
    9 other sponsors
  • 28.
    Not possible to specify1 trial
    230 other sponsors
  • 29.
    Pathological Conditions, Signs and Symptoms1 trial
    90 other sponsors
  • 30.
    Virus Diseases1 trial
    185 other sponsors

Partnered Research Centres

151 centres
location_city
assignment27
Algemeen Ziekenhuis Damiaan Oostende
Address
Gouwelozestraat 100, 8400 Ostend
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location_city
assignment304
Algemeen Ziekenhuis Delta
Address
Deltalaan 1, 8800 Roeselare
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location_city
assignment174
Algemeen Ziekenhuis Groeninge
Address
President Kennedylaan 4, 8500 Kortrijk
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location_city
assignment1
Algemeen Ziekenhuis Jan Portaels
Address
Gendarmeriestraat 65, 1800 Vilvoorde
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location_city
assignment64
Algemeen Ziekenhuis Klina
Address
Augustijnslei 100, 2930 Brasschaat
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location_city
assignment854
Amsterdam UMC
Address
De Boelelaan 1117, 1081 HV Amsterdam
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